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The gene vdr encodes a transcriptional regulator that regulates the expression of vitamin D-dependent genetics. The proteins contains a zinc-finger DNA-binding domain, a transcriptional activation domain and a ligand binding internet site. The proteins is a member of the steroid and thyroid junk receptor superfamily.

The T > C allele of the FokI polymorphism at the translation start off site of vdr results in a shortened protein that lacks a practical activation domain name. It is characterized by decreased binding to transcription factor IIB and lowered transactivation activity. The regularity of the version allele varies among ethnic groups. It has been implicated in variations in calcium compression, bone mineral density (BMD), and anthropometric measurements.

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